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Monograph
BioDiscovery 10: e8956
https://doi.org/10.7750/BioDiscovery.2013.10.1 (30 Dec 2013)
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  • Abstract
  • 1. Introduction
  • 2. Discovery of roscovitine
  • 3. Chemical synthesis and physicochemical properties of roscovitine
  • 4. Inhibition of CDKs by R-roscovitine (CYC202)
  • 5. CYC202 inhibits cell growth in vitro
  • 6. Anti-tumour activity of CYC202 in vivo
  • 7. Pharmacokinetics and pharmacodynamics of roscovitine
  • 8. Clinical results from investigation of Seliciclib in clinical trials
  • 9. Potential therapeutic applications of Roscovitine
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