Abstract

Introduction: the p53 protein

p53 and tumour suppression

Regulation of p53 by MDM2

Regulation of p53 by post-translational modification

A key role for p53 acetylation

p53 induction and activation

The DNA damage pathways: induction, activation and the importance of phosphorylation

The role of phosphorylation of p53 regulators in p53 induction by DNA damage

Attenuation of p53 induction by DNA damage

Mouse models expressing phosphorylation site mutants of p53 and its regulatory partners: what they tell us

Perspectives

References