Abstract

1. Dementia with late onset - many causes, (potentially) one disease

2. Amyloid deposition in the brain - what, where and how

3. APOE - a simple lipoprotein transporter, a major amyloid peptide metabolism modulator or in-between?

4. Neuronal cell death in dementia - it breaks where it's thin?

5. Breath of life (and death) - increased ATP production is associated with increased oxidative stress

6. Don't throw away, repair it - capacity to repair genotoxic damage may be critically important for the survival of adult CNS neurons

Conclusions

References