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BioDiscovery : Conference Abstract
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Larisa A. Balykova‡, Ludmila V. Ledyajkina§, Vladimir A. Trofimov‡, Alexei P. Vlasov‡, Irina S. Nazarova‡, Victor V. Revin‡
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Corresponding author: Larisa A. Balykova (larisabalykova@yandex.ru)
Received: 08 Jul 2017 | Published: 17 Jul 2017
© 2017 Larisa A. Balykova, Ludmila V. Ledyajkina, Vladimir A. Trofimov, Alexei P. Vlasov, Irina S. Nazarova, Victor V. Revin
This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Citation: Balykova L, Ledyajkina L, Trofimov V, Vlasov A, Nazarova I, Revin V (2017) New Mechanisms of Perinatal Hypoxia and Perspectives of Pathogenesis-oriented Treatment. BioDiscovery 20: e14945. https://doi.org/10.3897/biodiscovery.20.e14945
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Abstract
Aim: to study the contribution of structura-functional hemoglobin (Hb) disorders into perinatal hypoxia (PH) pathogenesis and possibility of its indicators using for pharmacotherapy efficiency assessment.90 full-term newborns with PH and 30 healthy ones were examined by clinical methods and Hb spectroscopy. Further children were randomized on 2 groups, received standard therapy and additionally L-carnitine.The indices, indicating Hb affinity to oxygen (1355/1550)/ (1375/1580) and ability to bind them (1355/1550) were less in hypoxia-affected newborns and got reduced at increased severity of PH. The indices of Hb ability to reject ligands (1375/1580) and Hb conformative alterations (1375/1172) were higher in hypoxia-affected neonates and increased simultaneously to PH severity. It means that in severe PH oxygen binding to Hb becomes insufficient. We have established the correlation between Hb conformations and clinical features in newborns with PH. Additional use of L-carnitine promoted restoration of Hb comformative properties and improvement of neurologic status.Our dates confirm the contribution of disorders of Hb structural and functional properties into PH pathogenesis and suggest, that Hb spectroscopy indices could be used as novel criteria of hypoxia severity and pharmaco-therapy efficiency.
Keywords
Perinatal Hypoxia, Pathogenesis-oriented Treatment, pharmacotherapy, L-carnitine
Presented at
World BioDiscovery Congress 2017
Funding program
No financial support.
Grant title
Iniiative research
Ethics and security
The study was approved by a local Ethic Commetee.
Conflicts of interest
No conflicts of interest.