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BioDiscovery : Conference Abstract
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Natalia V. Gromova‡, Victor V. Revin‡, Nadezhda V. Revina‡, Anastasiya N. Kukina‡, Elvira S. Revina‡, Anastasiya Yu. Samonova ‡, Ilya N. Solomadin‡, Alexander Yu. Tychkov‡, Inessa Ya. Moiseeva§
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Corresponding author: Natalia V. Gromova (nataly_grom@mail.ru)
Received: 14 Jul 2017 | Published: 17 Jul 2017
© 2017 Natalia Gromova, Victor Revin, Nadezhda Revina, Anastasiya Kukina, Elvira Revina, Anastasiya Samonova , Ilya Solomadin, Alexander Tychkov, Inessa Moiseeva
This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Citation: Gromova N, Revin V, Revina N, Kukina A, Revina E, Samonova A, Solomadin I, Tychkov A, Moiseeva I (2017) Change in morphometric and oxygen-binding properties of erythrocytes in vascular diseases patients. BioDiscovery 20: e15079. https://doi.org/10.3897/biodiscovery.20.e15079
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Abstract
Now cardiovascular diseases take a leading place among the main causes of death of population. The prevalence of vascular brain lesions, which are the main causes of hypertension and atherosclerosis of cerebral arteries about 800 to 100 thousand population and it does not tend to decrease in Russia, as in most industrialized countries.
By the Raman spectroscopy and laser interference microscopy methods were studied morphometric parameters and the oxygen binding properties of erythrocytes in vascular diseases patients with the different term of vascular diseases patients before and after treatment according to the accepted scheme.
It is shown that vascular diseases together with classic development mechanism are accompanied first of all with pathological changes from the direction of erythrocytes primarily changes in morphometric characteristics such as an area, the height of the phase (optical path difference), physical height. In addition, pathological forms erythrocytes such as echinocytes, stomatocytes, spherocytes met in large amounts in blood. In patients with cardiovascular diseases observed changes conformation of haemoglobin and erythrocytes impaired ability to bind and release oxygen, which can lead to incomplete release of oxygen from the oxyhaemoglobin its insufficient intake in the tissue and the development of tissue hypoxia.
These data suggest that in vascular diseases the high mortality rate can associated with disorders of the blood vessels, also with change in the morphometric characteristics of erythrocytes and conformation of haematoporphyrin of haemoglobin. In turn it leads to disruption of the main functions of the erythrocytes and it reduces oxygen-transport ability of erythrocytes.
Keywords
Cardiovascular diseases, Raman spectroscopy, laser interference microscopy, erythrocytes
Presenting author
Natalia V. Gromova (nataly_grom@mail.ru)
Funding program
This work was supported by the Russian Science Foundation, Grant. No. 15-15-10025.
Conflicts of interest
The authors declare that there is no conflict of interests regarding the publication of this paper.