BioDiscovery : Conference Abstract
Conference Abstract
Application of safe-by-design approach for curing osteoporosis – a lock at the future
expand article infoArmine Grigoryan, Iliyan Kolev§,|, Anelia Dimitrova, Margarita D. Apostolova|
‡ Department of General Biology and Pathological Physiology, Medical University-Pleven, Pleven, Bulgaria
§ Department of Pharmaceutical Sciences, Medical University-Varna, Varna, Bulgaria
| Institute of Molecular Biology, Bulgarian Academy of Sciences, Sofia, Bulgaria
Open Access


During the last years several studies have been performed to develop new materials for stimulation of bone healing and regeneration. Whilst it is known that osteoporotic bone is generally not cancellous in nature and has thin walls, the essential design paradigm of implants does not reflect this application.

We have proposed a simple system for assisted bone repair by in bone injection of “intelligent” polymers combined with nanodiamonds and progenitor cells. A Safe-by-Design approach was undertaken. It utilizes autologous stem cells transplantation in combination with supportive bioresorbable matrices and bioactive molecules for enhancing growth and repair. The endothelial progenitor cells obtained from peripheral blood of the same patient may be cultured in vitro in the presence of different stimuli and/or nanoparticles to undergo osteoblasts differentiation, prior to autologous transplantation. This injectable therapy could also be used for: (1) modifying the bone interior morphology, porosity and interconnectivity, which are extremely important for cell adhesion, proliferation and differentiation; (2) prophylactic treatment for high risk patients to prevent fractures, especially the hip and vertebrae; (3) providing exceptional repair of the osteoporotic bone by releasing pharmaceuticals to the specific sites with the purpose of accelerating healing, promoting angiogenesis, reducing the risk of infection, etc.


Osteoporosis, Safe-by-Design, "Intelligent" Polymers, Endothelial Progenitor Cells

Presenting author

Margarita D. Apostolova

Presented at

World Biodiscovery Congress 2017


The authors are grateful to the Bulgarian National Science Fund for the financial support under Grant DО-1-1126 and the EU - H2020 - Grant 646221

Hosting institution

Institute of Molecular Biology, Bulgarian Academy of Sciences, Sofia, Bulgaria

Conflicts of interest


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